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Organic Photothermal Materials Obtained Using Thermally Activated Delayed Fluorescence Design Principles.

Jana R Caine1, Heekyoung Choi1, Ryoga Hojo1

  • 1Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, V6T 1Z1, Canada) .

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|November 28, 2023
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Summary
This summary is machine-generated.

New organic small molecules offer efficient near-infrared light conversion for photothermal therapy. These materials show high photothermal conversion efficiencies and improved water dispersibility for potential biomedical applications.

Keywords:
Donor-Acceptor MaterialsNear-Infrared AbsorbancePhototheranosticsPhotothermal ConversionThermally Activated Delayed Fluorescence

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Organic Chemistry

Background:

  • Organic small molecules are promising for photothermal therapy due to biocompatibility and near-infrared absorption.
  • Near-infrared light absorption is crucial for deep tissue penetration in photothermal therapy.
  • Current inorganic materials present limitations in biocompatibility for therapeutic applications.

Purpose of the Study:

  • To develop novel organic small molecules with high photothermal conversion efficiencies (PCEs) for near-infrared (NIR) light absorption.
  • To investigate the structure-property relationships influencing PCEs in donor-acceptor organic materials.
  • To enhance the applicability of these organic materials through nanoparticle encapsulation for improved dispersion and efficacy.

Main Methods:

  • Synthesis and characterization of three donor-acceptor organic materials (DM-ANDI, O-ANDI, S-ANDI).
  • Photothermal conversion efficiency measurements under near-infrared irradiation.
  • Modification of thermally activated delayed fluorescence (TADF) materials to achieve low photoluminescence quantum yield (PLQY).
  • Encapsulation of materials into nanoparticles and aggregated organic dots.

Main Results:

  • Achieved high photothermal conversion efficiencies ranging from 46-68% for the synthesized organic materials.
  • Demonstrated strong near-infrared absorption properties for all three compounds.
  • Successfully encapsulated materials into nanoparticles and organic dots, improving water dispersibility and modulating PCEs.

Conclusions:

  • The developed donor-acceptor organic molecules are highly efficient for near-infrared photothermal therapy.
  • Rational molecular design, including reduced HOMO-LUMO overlap, is key to achieving high PCEs.
  • Nanoparticle encapsulation offers a viable strategy for enhancing the practical application of these organic photothermal agents in aqueous environments.