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Organic Photothermal Materials Obtained Using Thermally Activated Delayed Fluorescence Design Principles
Jana R Caine1, Heekyoung Choi1, Ryoga Hojo1
1Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, V6T 1Z1, Canada) .
Chemistry (Weinheim an Der Bergstrasse, Germany)
|November 28, 2023
Summary
New organic small molecules offer efficient near-infrared light conversion for photothermal therapy. These materials show high photothermal conversion efficiencies and improved water dispersibility for potential biomedical applications.
Area of Science:
- Materials Science
- Biomedical Engineering
- Organic Chemistry
Background:
- Organic small molecules are promising for photothermal therapy due to biocompatibility and near-infrared absorption.
- Near-infrared light absorption is crucial for deep tissue penetration in photothermal therapy.
- Current inorganic materials present limitations in biocompatibility for therapeutic applications.
Purpose of the Study:
- To develop novel organic small molecules with high photothermal conversion efficiencies (PCEs) for near-infrared (NIR) light absorption.
- To investigate the structure-property relationships influencing PCEs in donor-acceptor organic materials.
- To enhance the applicability of these organic materials through nanoparticle encapsulation for improved dispersion and efficacy.
Main Methods:
- Synthesis and characterization of three donor-acceptor organic materials (DM-ANDI, O-ANDI, S-ANDI).
- Photothermal conversion efficiency measurements under near-infrared irradiation.
- Modification of thermally activated delayed fluorescence (TADF) materials to achieve low photoluminescence quantum yield (PLQY).
- Encapsulation of materials into nanoparticles and aggregated organic dots.
Main Results:
- Achieved high photothermal conversion efficiencies ranging from 46-68% for the synthesized organic materials.
- Demonstrated strong near-infrared absorption properties for all three compounds.
- Successfully encapsulated materials into nanoparticles and organic dots, improving water dispersibility and modulating PCEs.
Conclusions:
- The developed donor-acceptor organic molecules are highly efficient for near-infrared photothermal therapy.
- Rational molecular design, including reduced HOMO-LUMO overlap, is key to achieving high PCEs.
- Nanoparticle encapsulation offers a viable strategy for enhancing the practical application of these organic photothermal agents in aqueous environments.
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