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Updated: Jul 9, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis, Photophysical Properties and Antioxidant Activity of Novel Quinoline Derivatives
Armen I Martiryan1,2, Gohar A Shahinyan3, Iskuhi L Aleksanyan4
1Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, Yerevan State University, Yerevan, 0025, Armenia. armart@ysu.am.
Abstract:
Novel quinoline derivatives were synthesized based on 6-amino-substituted quinoline, and antioxidant activity of these compounds is studied by p-nitroso-N,N-dimethylaniline assay. The rate of the reaction between OH radicals and quinoline derivatives is determined by photometric method and the obtained results are compared with that of well-known antioxidant vitamin C. Quinoline derivatives exhibit pronounced antioxidant activity, which strongly depends on the structural features of compounds. Photophysical properties such as UV-Vis absorption and fluorescence maxima, and Stokes shift are also reported. To reveal the potential application of novel quinoline derivatives as fluorescence probes the values of quantum yields are determined and the obtained results are explained in terms of structural features of compounds.
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