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Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
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Multiple angiosarcomas of both breasts: a case report.

Ryota Matsuda1, Michiyo Saimura2, Keisei Anan2

  • 1Department of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokurakita-Ward, Kitakyushu, Fukuoka, 802-0077, Japan. matsuda.r@kyudai.jp.

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Summary

This case report details a rare instance of multiple primary breast angiosarcomas in both breasts. Early diagnosis and prompt treatment, including surgery and chemotherapy, are crucial for managing this aggressive cancer.

Keywords:
AngiosarcomaBilateral breastsChemotherapyMetastasisPaclitaxelRadiotherapy

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Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Primary breast angiosarcoma is an exceptionally rare and aggressive malignancy.
  • This report presents a unique case of multifocal primary angiosarcoma occurring simultaneously in both breasts.

Purpose of the Study:

  • To report a rare case of bilateral primary breast angiosarcoma.
  • To highlight diagnostic challenges and treatment strategies for this uncommon condition.

Main Methods:

  • A 49-year-old woman presented with bilateral breast lesions initially missed by mammography and ultrasound.
  • Advanced imaging (MRI) revealed multiple masses, confirmed as well-differentiated angiosarcoma via core biopsy.
  • Treatment involved bilateral mastectomies, radiation, and subsequent chemotherapy for suspected metastases.

Main Results:

  • Histological examination confirmed multifocal well-differentiated angiosarcoma in both breasts.
  • Post-surgical CT revealed suspected metastases, which responded to weekly paclitaxel chemotherapy.
  • The patient underwent bilateral mastectomies and adjuvant therapies.

Conclusions:

  • Multifocal primary breast angiosarcoma is a rare diagnosis requiring high clinical suspicion.
  • Integrated treatment including surgery, radiation, and chemotherapy is essential.
  • Intensive follow-up is critical for managing patients with angiosarcoma.