Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

On shunting inhibition.

H C Tuckwell

    Biological Cybernetics
    |January 1, 1986
    PubMed
    Summary

    This study analyzes nerve cylinder excitation and inhibition interactions, finding shunting inhibition effects vary with synapse type. Optimal inhibition timing and spatial arrangement significantly impact signal amplification and EPSP amplitude at the soma.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A mathematical model for evaluating the impact of vaccination schedules: application to Neisseria meningitidis.

    Epidemiology and infection·2003
    Same author

    Epidemic spread and bifurcation effects in two-dimensional network models with viral dynamics.

    Physical review. E, Statistical, nonlinear, and soft matter physics·2001
    Same author

    Nature of equilibria and effects of drug treatments in some simple viral population dynamical models.

    IMA journal of mathematics applied in medicine and biology·2001
    Same author

    Cortical potential distributions and information processing.

    Neural computation·2000
    Same author

    Enhancement of epidemic spread by noise and stochastic resonance in spatial network models with viral dynamics.

    Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2000
    Same author

    Direct HIV testing in blood donations: variation of the yield with detection threshold and pool size.

    Transfusion·1999

    Area of Science:

    • Computational Neuroscience
    • Neuroscience
    • Mathematical Biology

    Background:

    • Understanding neural signal processing requires analyzing the interplay between excitatory and inhibitory synaptic inputs.
    • Synaptic action can be modeled as impulsive or sustained conductance changes, influencing neuronal responses.
    • Reversal potentials are crucial for accurately modeling synaptic integration and its impact on neuronal excitability.

    Purpose of the Study:

    • To analyze the interaction between excitation and inhibition in nerve cylinders, incorporating reversal potentials.
    • To investigate the impact of impulsive and sustained synaptic conductance changes on neuronal signaling.
    • To determine the conditions under which shunting inhibition is most effective and its influence on excitatory postsynaptic potentials (EPSPs).

    Main Methods:

    • Exact analytical solutions using Green's functions for the cable equation with reversal potentials and impulsive conductance changes.
    • Numerical integration of the cable equation using the Crank-Nicolson method for sustained conductance changes in finite nerve cylinders.
    • Analysis of amplification factors and EPSP amplitudes under varying spatial and temporal input configurations.

    Main Results:

    • Exact amplification factors for inhibitory input following excitatory input were derived, showing dependence on spatial synapse separation.
    • Shunting inhibition was observed for both impulsive and sustained conductance changes, with distinct characteristics.
    • Maximum shunting inhibition effectiveness occurred when inhibition rapidly followed excitation; EPSP amplitude correlated with inhibitory synapse distance.

    Conclusions:

    • The study provides exact mathematical frameworks for understanding excitation-inhibition interactions in nerve cylinders.
    • Both the timing and spatial distribution of synaptic inputs critically modulate neuronal responses, particularly shunting inhibition.
    • These findings offer insights into neural computation and the mechanisms underlying synaptic integration in complex neural circuits.

    Related Experiment Videos