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Monitoring of serum 25-(OH)D level in infants and its correlation with bone density and development

Dan Ming1, Rongxiu Zheng1

  • 1Department of Pediatrics, Tianjin Medical University General Hospital, Tianjin, 300052, China. m18322567998@163.com.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|November 28, 2023
PubMed

Insights

Serum 25-hydroxyvitamin D (25(OH)D) levels are vital for infant bone health. Low 25(OH)D correlates with decreased bone density and impaired bone metabolism, highlighting the importance of adequate vitamin D status.

Area of Science:

  • Pediatrics
  • Nutritional Science
  • Biochemistry

Background:

  • Serum 25-hydroxyvitamin D (25(OH)D) is a key indicator of vitamin D nutritional status.
  • Vitamin D (VD) is essential for calcium and phosphorus absorption, directly impacting bone health.
  • Infant bone development and density are critical health parameters requiring investigation.

Purpose of the Study:

  • To investigate the correlation between serum 25(OH)D levels and bone density in infants.
  • To analyze the relationship between 25(OH)D and other bone metabolism markers, including calcium, phosphorus, alkaline phosphatase (ALP), and parathyroid hormone (PTH).

Main Methods:

  • Bone density was measured using ultrasound in 150 infants aged 0-3 years.
  • Infants were categorized into normal (N) and abnormal (ABN) bone density groups.
  • Serum levels of 25(OH)D, calcium, phosphorus, ALP, and PTH were analyzed and correlated with bone density.

Main Results:

  • The ABN group exhibited significantly lower 25(OH)D, calcium, and phosphorus levels, and higher ALP and PTH levels compared to the N group (P<0.05).
  • Serum 25(OH)D showed a strong positive correlation with bone density (r=0.918, P<0.01).
  • 25(OH)D levels were positively associated with calcium and phosphorus, and negatively associated with ALP and PTH.

Conclusions:

  • Elevated serum 25(OH)D is crucial for preventing abnormal bone density in infants.
  • Maintaining adequate 25(OH)D levels supports healthy bone metabolism and improves overall infant bone health.
  • This study underscores the importance of monitoring and ensuring sufficient vitamin D status in infants for optimal skeletal development.

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