[Atherogenic index and its association with acute coronary ischemic syndrome mortality]

Area of Science:

• Cardiology
• Lipid Metabolism
• Biomarkers

Context:

• Cardiovascular diseases remain a leading cause of mortality globally.
• Lipid metabolism plays a crucial role in the development of atherosclerosis and cardiovascular events.
• Existing risk stratification models for acute coronary syndromes often require complex assessments.

Purpose:

• To evaluate the efficacy of total cholesterol/high-density lipoprotein (TC/HDL-C) and low-density lipoprotein/high-density lipoprotein (LDL-C/HDL-C) ratios as early prognostic markers.
• To determine if these lipid ratios can predict 30-day mortality and major adverse cardiovascular events in patients with ST-elevation acute coronary syndrome (STE-ACS).

Summary:

• A study involving 265 patients with STE-ACS analyzed mortality and major cardiovascular events at 30-day follow-up.
• Patients were stratified into four groups based on TC/HDL-C and LDL-C/HDL-C ratios, with cut-off points at 6.9 and 2.7, respectively.
• Higher ratios were associated with increased cardiovascular death and arrhythmia, particularly in the third group.

Impact:

• The findings suggest that TC/HDL-C and LDL-C/HDL-C ratios can serve as valuable, accessible prognostic tools for early risk stratification in STE-ACS patients.
• These lipid indices offer a simple method to identify high-risk individuals, potentially guiding timely therapeutic interventions.
• This research contributes to improving the management and outcomes of patients experiencing acute coronary events.