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Updated: Jul 9, 2025

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
Published on: June 23, 2014
[Association between vascularization and its impact for recurrence of juvenile nasoangiofibroma]
Ana Karen Castro-Rodríguez1, Marcos Flavio Roque-Moreno1, María Fernanda Galindo-Tapia2
1Instituto Mexicano del Seguro Social, Centro Médico Nacional del Bajío, Hospital de Especialidades No. 1, Servicio de Otorrinolaringología y Cirugía de Cabeza y Cuello. León Guanajuato, México.
Background:
Juvenile nasoangiofibroma (JNA) is a rare, highly vascular, locally aggressive benign tumor which affects male adolescents. It accounts for 0.05-0.5% of head and neck tumors with recurrence rates of 6-50%. The internal maxillary artery is the main source of JNA.
Objective:
To evaluate the relationship between vascular supply as a factor associated with JNA recurrence.
Material And Methods:
An cohort study was performed in patients diagnosed with NAJ. We collected demographic data, vascular contribution by angiography and tomography results to classify them according to their stage (Radkowski classification), and if they received adjuvant radiotherapy. Post-surgical CT scans were requested to evaluate recurrence and if any of the variables were related to this.
Results:
A sample of 14 male patients who met the inclusion criteria was collected. The mean age was 14.71 ± 4.08 years. According to Radkowski classification, stage IA, IIA and IIC were reported in 14.3%, IIB and IIB in 7.1% and IIIA in 42.9%. 42.9% had recurrence and out of these, 66.7% had irrigation of the right carotid system and the same percentage of patients received radiotherapy as adjuvant treatment.
Conclusions:
There is a tendency in tumor recurrence associated with vascular contribution from the right carotid system, as well as with patients who received radiotherapy.
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