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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

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Published on: July 8, 2012

Murine malaria decreases hemopoietic stem cells.

P H Silverman, J C Schooley, L J Mahlmann

|February 1, 1987

Summary

Malaria infection in mice reduces erythropoietic activity and hematopoietic stem cells (CFU-S). Despite adequate erythropoietin (EP) production, stem cell depletion likely contributes to malaria

Area of Science:

Hematology
Immunology
Infectious Diseases

Background:

Anemia and immunosuppression are key malaria outcomes.
The precise causes of these outcomes remain unclear.

Purpose of the Study:

To investigate erythropoietin (EP) production adequacy during malaria.
To assess the impact on hematopoietic stem cells (CFU-S).

Main Methods:

Mice infected with Plasmodium species were exposed to simulated high altitude.
Plasma EP levels were measured via bioassay and RIA.
Erythropoiesis and CFU-S content were assessed using radioiron incorporation and spleen colony assays.

Main Results:

Erythropoietic activity decreased in bone marrow and spleen with progressing infection.

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CFU-S content and marrow cellularity declined as parasitemia increased.

All Plasmodium species stimulated EP production during peak parasitemia.

Conclusions:

Adequate EP is available during malaria, but erythropoiesis is suppressed.
Depletion of CFU-S, potentially without compensatory turnover, may drive malaria's pathology.