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Related Experiment Videos

[Rhinomanometry study of patients with respiratory allergy].

A Ghaem, J P Dessanges, A Lockhart

    Bulletin Europeen De Physiopathologie Respiratoire
    |September 1, 1986
    PubMed
    Summary
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    Nasal allergen provocation tests using rhinomanometry are accurate for diagnosing allergic respiratory disease. High serum specific IgE levels predict nasal response, unlike skin tests which may show false positives.

    Area of Science:

    • Allergy and Immunology
    • Otorhinolaryngology
    • Respiratory Medicine

    Background:

    • Accurate diagnosis of nasal allergic disease is crucial for effective treatment.
    • Current diagnostic methods like skin tests and serum IgE measurements have limitations in predicting nasal response.

    Purpose of the Study:

    • To evaluate the diagnostic accuracy of nasal allergen provocation tests (NPT) combined with rhinomanometry.
    • To compare NPT results with skin tests and serum specific IgE (RAST) levels.

    Main Methods:

    • 886 patients with suspected allergic respiratory disease underwent skin tests, serum specific IgE measurement, and nasal challenge.
    • Nasal airway resistance was measured using rhinomanometry before and after allergen challenge.
    • The threshold dose (Dl) for a 100% increase in nasal resistance was determined.

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    Main Results:

    • Rhinomanometry showed comparable results for anterior and posterior measurements.
    • Nasal resistance increase correlated with allergen dose, and a significant inverse relationship existed between baseline resistance (Ri) and threshold dose (Dl).
    • High serum specific IgE accurately predicted nasal responsiveness, while skin tests often yielded positive results for allergens without a nasal effect.

    Conclusions:

    • Nasal allergen provocation tests with rhinomanometric measurement of nasal resistance are a valuable diagnostic tool for nasal allergic disease.
    • This method offers superior accuracy in identifying clinically relevant allergens compared to skin tests alone.
    • Serum specific IgE levels are a reliable indicator of nasal allergic responsiveness.