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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Relationship between serum interleukin-6 levels and severity of coronary artery disease undergoing percutaneous
Nadia Bouzidi1,2, Habib Gamra3,4
1Cardiothrombosis Research Laboratory, LR12SP16 University of Monastir, Monastir, 5000, Tunisia. nadiabouzidi1@outlook.fr.
Insights
Interleukin-6 (IL-6) levels correlate with coronary artery disease (CAD) severity, as measured by the Gensini score. Elevated IL-6 may serve as a marker for evaluating myocardial necrosis in patients with myocardial infarction.
Area of Science:
- Cardiology
- Immunology
- Biomarkers
Background:
- Cytokines, including interleukin-6 (IL-6), are implicated in atherosclerosis.
- The relationship between IL-6 and coronary artery disease (CAD) severity requires further investigation.
Purpose of the Study:
- To examine the association between IL-6 levels and the angiographic severity of CAD.
- To evaluate IL-6 as a potential predictor of myocardial infarct size.
Main Methods:
- A study involving 310 CAD patients and 210 controls.
- CAD severity assessed using Gensini score (GS), stenosis degree, and vessel count.
- Patients stratified into high (≥9.5 pg/mL) and low (<9.5 pg/mL) IL-6 groups.
Main Results:
- IL-6 levels were significantly higher in CAD patients than controls.
- High IL-6 levels correlated with higher GS (p=0.027) but not stenosis degree or vessel score.
- ROC analysis indicated IL-6 is a powerful predictor of infarct size in myocardial infarction patients (AUC: 0.941).
Conclusions:
- IL-6 levels are associated with CAD severity, particularly when assessed by GS.
- IL-6 shows potential as a valuable biomarker for assessing myocardial necrosis, especially in STEMI patients.
Background:
Cytokines play a potential role in atherosclerosis pathogenesis and progression. We investigated the association of interleukin-6 (IL-6) with the angiographic severity of coronary artery disease (CAD).
Methods:
Three hundred ten angiografically diagnosed CAD patients and 210 controls were enrolled in this study. CAD patients were stratified according to IL-6 cut-off value into high levels IL-6 group (≥ 9.5 pg/mL) and low levels IL-6 group (< 9.5 pg/mL). The severity of CAD was assessed according to Gensini score (GS), artery stenosis degree and the number of vessels involved. The mean age was 60.3 ± 11.0 years.
Results:
The level of IL-6 in patients was increased compared to controls and ranged from 1.5 to 3640.0 pg/mL. High levels of IL-6 were significantly associated with high levels of GS (> 40) but not with stenosis degree and vessel score. GS levels were significantly more elevated in patients with high levels of IL-6 group than in low IL6 levels patients (60.6 ± 39.5 vs 46.7 ± 37.2; p = 0.027). The analysis of the ROC curve performed in myocardial infarction patients showed that IL-6 (AUC: 0.941 (CI 95% 0.886, 0.997; p < 0.001) could be a powerful predictor marker in evaluating the infarct size after myocardial infarction when compared to myonecrosis biomarkers.
Conclusions:
IL-6 levels were associated with the severity of CAD assessed by the GS. Based on the highest levels of IL-6 measured in patients with STEMI, our study strongly suggests that IL-6 could be a powerful marker in evaluating the myocardial necrosis.
Trial Registration:
ClinicalTrials.gov Number: NCT03075566 (09/03/2017).
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