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Correlation between dietary inflammation and mortality among hyperlipidemics.

Lili Wang1, Tao Liu2, Qingdui Zhang1

  • 1Department of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, 221000, Xuzhou, China.

Lipids in Health and Disease
|November 29, 2023
PubMed
Summary

Higher Dietary Inflammatory Index (DII) levels are linked to increased mortality risk in hyperlipidaemia patients. This study confirms a positive, linear association between DII and death risk in this population.

Keywords:
Adult populationCohort studyDietary inflammatory indexHyperlipidaemiaRisk of death

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Area of Science:

  • Nutrition Science
  • Cardiovascular Health
  • Epidemiology

Background:

  • The Dietary Inflammatory Index (DII) is a recognized indicator for hyperlipidaemia.
  • Uncertainty exists regarding the DII's prognostic value in hyperlipidaemic individuals.

Purpose of the Study:

  • To analyze DII levels in relation to mortality risk among hyperlipidaemic individuals.
  • To determine a prospective correlation between DII and mortality in this population.

Main Methods:

  • Analysis of 14,460 hyperlipidaemic subjects from the NHANES (2001-2010).
  • Follow-up for all-cause mortality until December 31, 2019.
  • Utilized tertiles of DII, Kaplan-Meier curves, Cox regression, RCS, and sensitivity analyses.

Main Results:

  • 3170 (21.92%) all-cause deaths observed over a 148-month follow-up.
  • Higher DII levels significantly correlated with increased mortality risk (HR: 1.06 continuous; 1.22 categorical).
  • A linear association between DII and mortality was confirmed by RCS analysis.

Conclusions:

  • A positive and linear association exists between DII levels and mortality risk in hyperlipidaemic patients.