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Immune checkpoint inhibitors for multiple myeloma immunotherapy

Zhaoyun Liu1, Xintong Xu1, Hui Liu1

  • 1Department of Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.

Experimental Hematology & Oncology
|November 29, 2023
PubMed

Multiple myeloma (MM) is related to immune disorders, recent studys have revealed that immunotherapy can greatly benefit MM patients. Immune checkpoints can negatively modulate the immune system and are closely associated with immune escape. Immune checkpoint-related therapy has attracted much attention and research in MM. However, the efficacy of those therapies need further improvements. There need more thoughts about the immune checkpoint to translate their use in clinical work. In our review, we aggregated the currently known immune checkpoints and their corresponding ligands, further more we propose various ways of potential translation applying treatment based on immune checkpoints for MM patients.

Keywords:
CTLA-4Immune checkpointMultiple myelomaTIGITtreatment strategy

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