Triglyceride-glucose index, renal function and cardiovascular disease: a national cohort study
Cancan Cui1, Lin Liu1, Te Zhang1
1China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Insights
The triglyceride-glucose (TyG) index and impaired renal function significantly increase cardiovascular disease risk. Renal function partially mediates the link between the TyG index and cardiovascular events.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Metabolic Syndrome
Background:
- The triglyceride-glucose (TyG) index is an emerging marker for cardiovascular disease (CVD) risk.
- The role of renal function in the association between the TyG index and CVD remains unclear.
Purpose of the Study:
- To investigate the combined association of the TyG index and renal function with CVD.
- To evaluate the mediating role of renal function in the TyG index-CVD relationship.
Main Methods:
- Cohort study utilizing data from the China Health and Retirement Longitudinal Study (CHARLS).
- Participants were free of CVD at baseline.
- Triglyceride-glucose (TyG) index calculated as Ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2].
- Renal function assessed by estimated glomerular filtration rate (eGFR).
- Cox regression and mediation analyses were performed.
Main Results:
- A total of 6,496 participants were analyzed.
- Higher TyG index and lower eGFR were independently associated with increased CVD risk.
- The combination of a high TyG index and low eGFR showed the highest CVD risk (HR, 1.870).
- Decreased eGFR significantly mediated 29.6% of the association between the TyG index and CVD.
Conclusions:
- Elevated TyG index and impaired renal function synergistically increase cardiovascular disease risk.
- Renal function plays a significant mediating role in the relationship between the TyG index and cardiovascular risk.
Background:
The triglyceride-glucose (TyG) index is a predictor of cardiovascular diseases; however, to what extent the TyG index is associated with cardiovascular diseases through renal function is unclear. This study aimed to evaluate the complex association of the TyG index and renal function with cardiovascular diseases using a cohort design.
Methods:
This study included participants from the China Health and Retirement Longitudinal Study (CHARLS) free of cardiovascular diseases at baseline. We performed adjusted regression analyses and mediation analyses using Cox models. The TyG index was calculated as Ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Renal function was defined by the estimated glomerular filtration rate (eGFR).
Results:
A total of 6 496 participants were included in this study. The mean age of the participants was 59.6 ± 9.5 years, and 2996 (46.1%) were females. During a maximum follow-up of 7.0 years, 1 996 (30.7%) people developed cardiovascular diseases, including 1 541 (23.7%) cases of heart diseases and 651 (10.0%) cases of stroke. Both the TyG index and eGFR level were significantly associated with cardiovascular diseases. Compared with people with a lower TyG index (median level) and eGFR ≥ 60 ml/minute/1.73 m2, those with a higher TyG index and decreased eGFR had the highest risk of cardiovascular diseases (HR, 1.870; 95% CI 1.131-3.069). Decreased eGFR significantly mediated 29.6% of the associations between the TyG index and cardiovascular diseases.
Conclusions:
The combination of a higher TyG index and lower eGFR level was associated with the highest risk of cardiovascular diseases. Renal function could mediate the association between the TyG index and cardiovascular risk.
More Related Videos
06:13Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Related Concept Videos
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:27Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes: