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Adipocytic Differentiation in a Sertoli Cell Tumor
Jordan Molina1, Ali Dabaja2, Nilesh Gupta1,3
1Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA.
International Journal of Surgical Pathology
|November 29, 2023
Summary
This study reports a rare case of a Sertoli cell tumor with adipocytic differentiation in the testis. This finding expands the known features of testicular sex cord-stromal tumors.
Area of Science:
- Oncology
- Pathology
- Urology
Background:
- Testicular sex cord-stromal tumors are neoplasms originating from the supportive tissues of the testes.
- Leydig cell tumors and Sertoli cell tumors are common subtypes.
- Adipocytic differentiation has been previously noted in Leydig cell tumors but not other sex cord-stromal tumors.
Purpose of the Study:
- To report a novel case of a Sertoli cell tumor exhibiting adipocytic differentiation.
- To highlight a potential distinguishing feature in testicular neoplasms.
Main Methods:
- Case study of a 48-year-old male patient with an incidentally discovered testicular mass.
- Surgical resection (partial orchiectomy) of the tumor.
- Histopathological examination and immunohistochemistry (beta-catenin staining).
Main Results:
- A 1.1 cm testicular mass was diagnosed as a Sertoli cell tumor.
- The tumor displayed strong and diffuse nuclear and cytoplasmic positivity for beta-catenin.
- Novel adipocytic differentiation was observed within the Sertoli cell tumor.
Conclusions:
- This case represents the first report of adipocytic differentiation in a Sertoli cell tumor.
- Adipocytic differentiation may occur in various testicular sex cord-stromal tumors, not exclusively Leydig cell tumors.
- Further research is needed to understand the implications of this finding.
