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Microproteinuria in children with vesicoureteric reflux
British Journal of Urology
|December 1, 1986
Summary
Children with vesicoureteric reflux (VUR) show increased microproteinuria, indicating altered kidney function. This protein excretion correlates with VUR severity and renal scarring, suggesting tubular dysfunction.
Area of Science:
- Pediatric Nephrology
- Urology
- Biochemistry
Background:
- Vesicoureteric reflux (VUR) is a common condition in children that can lead to kidney damage.
- Microproteinuria, the excretion of small amounts of protein in the urine, is an early indicator of kidney dysfunction.
- Assessing microproteinuria in VUR patients can help monitor disease progression and treatment effectiveness.
Purpose of the Study:
- To investigate the presence and significance of microproteinuria in children with VUR.
- To correlate microproteinuria levels with VUR severity and renal scarring.
- To evaluate the utility of albumin and retinol binding protein (RBP) as biomarkers for tubular dysfunction in VUR.
Main Methods:
- Urine samples from 36 children with VUR and 36 controls were analyzed for albumin, RBP, and creatinine using ELISA.
- Infection and hypertension were excluded in all participants.
- VUR severity and renal scarring were assessed to correlate with protein excretion levels.
Main Results:
- Albumin and RBP excretion were significantly higher in children with VUR compared to controls.
- Proteinuria levels increased with greater VUR severity and the presence of renal scarring.
- A strong correlation was found between the degree of microproteinuria and VUR severity, indicating tubular dysfunction.
Conclusions:
- Children with VUR exhibit altered glomerular and tubular protein handling, leading to microproteinuria.
- Microproteinuria serves as a valuable indicator of tubular dysfunction and disease severity in VUR.
- Further research is needed to assess the impact of medical and surgical interventions on microproteinuria in VUR patients.
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