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Updated: Aug 15, 2026
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
The Outcome of Mandibular Distraction Osteogenesis in Infants with Severe Pierre Robin Sequence in Vietnam
Dang Hoang Thom1,2, Vu Ngoc Lam3, Tran Thiet Son1
1Hanoi Medical University, Hanoi, Vietnam.
Insights
Mandibular distraction osteogenesis (MDO) effectively resolves airway issues in Pierre Robin Sequence (PRS) patients. Early MDO treatment in PRS patients improves outcomes and reduces complications.
Area of Science:
- Craniofacial Surgery
- Pediatric Otolaryngology
- Congenital Anomalies
Background:
- Pierre Robin Sequence (PRS) presents significant airway challenges in infants.
- Conservative management of PRS airway issues can be insufficient.
- Mandibular hypoplasia is a key feature of PRS, impacting respiration.
Purpose of the Study:
- To report the single-center experience with MDO in PRS patients.
- To evaluate the efficacy and safety of MDO for PRS airway management.
- To identify factors influencing MDO outcomes in PRS.
Main Methods:
- Longitudinal analysis of PRS patients undergoing MDO (2019-2021).
- Inclusion criteria: PRS, failed conservative therapy, MDO with internal distractors, no prior treatment.
- Evaluation of demographics, surgical results, and postoperative complications.
Main Results:
- 73 PRS patients met inclusion criteria for MDO.
- The MDO strategy demonstrated no procedural difficulties.
- Most patients with prior tracheostomies were decannulated; others avoided tracheostomy.
- Lower success and higher complication rates were observed in patients with pre-existing tracheotomies or MDO after 2 months of age.
- Associated conditions like laryngomalacia or cardiac defects did not predict MDO failure.
Conclusions:
- MDO is an effective surgical intervention for managing airway obstruction in PRS.
- Timely MDO intervention, especially before 2 months of age and without prior tracheotomy, is associated with better outcomes.
- MDO can successfully prevent or resolve respiratory distress in PRS patients.
Abstract:
The purpose of this study was to provide the experience of a single center with mandibular distraction osteogenesis (MDO) in Pierre Robin Sequence (PRS) patients. A longitudinal research analysis was conducted to identify PRS patients who underwent MDO at Vietnam National Children's Hospital between 2019 and 2021. The following criteria were used to determine inclusion: 1) those pediatric patients with PRS who were not well handled with conservative therapy, 2) those who received MDO with internal mandibular distractors, and 3) no previous treatment elsewhere. Demographic data, postoperative complications, and surgical results were all evaluated. The inclusion criteria were met by 73 patients. There were no difficulties associated with our distraction strategy. The majority of individuals with tracheostomies were successfully decannulated, and the remainder were able to avoid tracheostomies. Using MDO in PRS is an effective technique to avoid future airway issues. The success rate was lower and the complication rate higher for patients who had a tracheotomy before distraction and for those who underwent distraction at an age older than 2 months. The presence of laryngomalacia, gastric reflux disease, cardiac abnormalities, and GI anomalies did not increase the likelihood of MDO failure in PRS patients.
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