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Polyelectrolyte-Cation Complexes Using PAsp-Sr Complexes Induce Biomimetic Mineralization with Antibacterial Ability.

Yuedan Xu1, Dongni Shen1, Zihuai Zhou1

  • 1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, 310000, China.

Advanced Healthcare Materials
|November 29, 2023
PubMed
Summary

This study introduces a novel biomimetic mineralization technique using strontium and fluorine to remineralize dentin. The new method restores dentin

Keywords:
antibacterialdental cariesintrafibrillar mineralizationpolyelectrolyte-calcium complexes pre-precursor processstrontium

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Area of Science:

  • Biomaterials Science
  • Dental Materials
  • Nanotechnology

Background:

  • Remineralizing dentin with antibacterial properties remains a significant dental challenge.
  • Previous polyelectrolyte-calcium complexes precursor (PCCP) processes enabled rapid collagen mineralization.

Purpose of the Study:

  • To explore an expanded PCCP concept by substituting calcium with strontium for enhanced dentin remineralization.
  • To develop an antibacterial and biocompatible dentin remineralization method.

Main Methods:

  • Utilized poly-aspartic acid-strontium (PAsp-Sr) suspension followed by a phosphate-fluoride solution for biomimetic mineralization.
  • Employed techniques including TEM, 3D STORM, EDX, FTIR, and HRTEM-SAED for characterization.
  • Conducted in vitro and in vivo antibacterial assays against Streptococcus mutans.
  • Performed cytotoxicity and oral mucosa irritation tests.

Main Results:

  • Successfully achieved biomimetic mineralization of collagen fibrils and demineralized dentin using Sr&F-codoped hydroxyapatite (HAp).
  • Demonstrated significant in vitro and in vivo antibacterial activity against Streptococcus mutans.
  • Restored mechanical properties (elastic modulus, microhardness) of demineralized dentin to near-intact levels.
  • Confirmed excellent biocompatibility of the mineralization mediums.

Conclusions:

  • The expanded PCCP concept, using strontium and fluorine, offers a promising approach for creating antibacterial remineralized dentin.
  • This biomimetic mineralization technology yields ion-doped HAp with excellent biocompatibility and restored mechanical integrity.
  • Opens new avenues for advanced dental restorative materials with enhanced functionalities.