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Role of ustekinumab in treatment of ulcerative colitis: a narrative review

Mauro Grova1, Alessandro Vitello2, Mariella Mannino3

  • 1Digestive Endoscopy Unit, Department of Medicine, "Villa Sofia-Cervello" Hospital, Palermo, 90100, Italy.

Immunotherapy
|November 29, 2023
PubMed

The therapeutic armamentarium for gastroenterologists in treating ulcerative colitis (UC) has been rapidly growing since the introduction of monoclonal antibodies directed against anti-TNFs. Ustekinumab is a monoclonal antibody binding the shared p40 subunit of IL-12 and IL-23, and the inhibition of these two cytokines, implicated in host response to microbial pathogens, has demonstrated clinical efficacy in different immune-mediated diseases, including moderate-to-severe UC. This narrative review summarizes the newest clinical evidence regarding the efficacy, effectiveness and safety of ustekinumab in moderate-to-severe UC, including specific situations (pregnancy, breastfeeding, elderly/pediatric populations, extraintestinal manifestations, acute severe UC, pouchitis and dual biological therapy). Finally, positioning is discussed in light of the existing evidence.

Keywords:
IL-12IL-23biologic therapyinflammatory bowel diseasepositioningulcerative colitisustekinumab

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