Sexually dimorphic opioid distribution in the preoptic area: manipulation by gonadal steroids

A striking sexual dimorphism has been found in the density of Met-enkephalin immunoreactive fibers in the periventricular region of the preoptic area in the rat: the enkephalinergic fiber system is much denser in females. The expression of this female-typical fiber plexus is regulated by the actions of gonadal steroids both during development and in adulthood. In light of abundant evidence demonstrating the ability of the opioid peptides to modulate various sexually differentiated neuroendocrine processes and behaviors, this dimorphic system may represent an important anatomical substrate underlying these functions.