Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Navigational deficits in weaver mutant mice.

R Lalonde, M I Botez

    Brain Research
    |November 19, 1986
    PubMed
    Summary

    Weaver mutant mice exhibit cerebellar granule cell degeneration, leading to impaired spatial learning and memory. These findings suggest the cerebellum is crucial for spatial orientation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Corticosterone effects on postnatal cerebellar development in mice.

    Neurochemistry international·2023
    Same author

    Argon plasma coagulation treatment of anal high-grade squamous intraepithelial lesions in men who have sex with men living with HIV: results of a 2-year prospective pilot study.

    HIV medicine·2017
    Same author

    The future is now: model-based clinical trial design for Alzheimer's disease.

    Clinical pharmacology and therapeutics·2015
    Same author

    Behavioral differentiation of mice exposed to a water tank social interaction test.

    Behavioural processes·2014
    Same author

    Behavioral and neurochemical effects of dietary methyl donor deficiency combined with unpredictable chronic mild stress in rats.

    Behavioural brain research·2013
    Same author

    Neurobehavioral performances and brain regional metabolism in Dab1(scm) (scrambler) mutant mice.

    Behavioural brain research·2013

    Area of Science:

    • Neuroscience
    • Genetics
    • Behavioral Biology

    Background:

    • Weaver mutant mice display a specific degeneration of cerebellar granule cells.
    • The cerebellum's role in motor control is well-established, but its contribution to cognitive functions like spatial orientation is less understood.

    Purpose of the Study:

    • To investigate the cognitive deficits associated with cerebellar granule cell degeneration in weaver mutant mice.
    • To explore the functional role of the cerebellum in spatial orientation using a behavioral paradigm.

    Main Methods:

    • Behavioral testing of weaver mutant mice and normal littermate controls in a water maze.
    • Assessment of spatial learning and memory through parameters such as time to reach the platform and error rates.

    Main Results:

    • Weaver mutant mice demonstrated significantly more errors compared to normal mice during the water maze task.
    • Mutant mice required a longer latency to locate the submerged platform, indicating impaired spatial navigation.
    • The observed behavioral deficits correlate with the known cerebellar pathology in weaver mutants.

    Conclusions:

    • Cerebellar granule cell degeneration in weaver mutants leads to significant impairments in spatial learning and memory.
    • These findings support a critical role for the cerebellum in spatial orientation and navigation.
    • The weaver mouse model provides valuable insights into the neurobiological underpinnings of cerebellar contributions to cognitive functions.

    Related Experiment Videos