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Updated: Jul 9, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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[Oncolytic viruses: Actors and deliverers of therapeutic proteins against tumors]

Ana Houel1, Johann Foloppe2

  • 1UMRS 1 135 Sorbonne université, Paris, France - Inserm U1135, Paris, France - Équipe « Microenvironnement immunitaire et immunothérapie », centre d'immunologie et des maladies infectieuses (Cimi), faculté de médecine, Sorbonne université, Paris, France - Transgene, Illkirch-Graffenstaden, France.

Medecine Sciences : M/S
|November 29, 2023
PubMed

Insights

Oncolytic viruses (OV) are engineered to target cancer cells, enhancing immunotherapy by delivering therapeutic molecules directly to tumors. Research focuses on improving OV effectiveness and delivery for better cancer treatment outcomes.

Area of Science:

  • Virology
  • Immunology
  • Oncology

Context:

  • Viruses naturally target cancer cells, offering a basis for novel cancer therapies.
  • Oncolytic viruses (OV) are being explored as a promising avenue in cancer immunotherapy.
  • Genetic modification of OV allows for targeted delivery of therapeutic molecules within the tumor microenvironment.

Purpose:

  • To explore the potential of oncolytic viruses (OV) as vectors for cancer immunotherapy.
  • To enhance antitumor responses by utilizing OV to express therapeutic molecules directly in tumors.
  • To investigate strategies for improving OV efficacy, including overcoming immune system neutralization and enhancing tumor delivery.

Summary:

  • Oncolytic viruses (OV) demonstrate a unique ability to selectively infect and lyse cancer cells.
  • Genetically engineered OV can express therapeutic molecules, augmenting antitumor immune responses and reducing systemic side effects.
  • Current research aims to prolong OV persistence and improve their infiltration into tumor tissues.

Impact:

  • Oncolytic virus therapy represents a significant advancement in cancer immunotherapy.
  • Targeted delivery of therapeutics via OV offers a more effective and safer treatment modality.
  • Ongoing research promises to optimize OV-based treatments for improved patient outcomes in oncology.

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