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[Multigenerational epigenetic inheritance in human: the past, present and perspectives]
1Univ. Rennes, EHESP, Inserm, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, 9 avenue Léon Bernard, 35000 Rennes, France.
Biologie Aujourd'Hui
|November 29, 2023
Summary
Environmental factors can alter individual development, leading to persistent epigenetic changes that may be inherited across generations. Human epigenetic research explores these potential transgenerational effects, similar to those seen in model organisms.
Area of Science:
- Developmental biology
- Epigenetics
- Human health
Context:
- Individual development can be modified by environmental factors.
- Phenotypic changes may persist and be inherited across generations.
- Epigenetic alterations are key mechanisms for this inheritance.
Purpose:
- To investigate the potential for transgenerational epigenetic inheritance in humans.
- To review recent human epigenetic research findings.
- To link environmental exposures to long-term health outcomes.
Summary:
- Environmental factors like pollution and stress influence development.
- The Developmental Origin of Human Disease theory highlights early-life impacts.
- Epigenetic mechanisms mediate the transmission of acquired traits and disease predispositions across generations.
Impact:
- Understanding epigenetic inheritance is crucial for public health.
- Early-life environmental interventions could prevent future diseases.
- This research informs strategies for mitigating environmental health risks.
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