Natural product biosynthetic potential reflects macroevolutionary diversification within a widely distributed
Sandra Godinho Silva1,2, Masun Nabhan Homsi3, Tina Keller-Costa1,2
1Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal.
Importance:
This is the most comprehensive study performed thus far on the biosynthetic potential within the Flavobacteriaceae family. Our findings reveal intertwined taxonomic and natural product biosynthesis diversification within the family. We posit that the carbohydrate, peptide, and secondary metabolism triad synergistically shaped the evolution of this keystone bacterial taxon, acting as major forces underpinning the broad host range and opportunistic-to-pathogenic behavior encompassed by species in the family. This study further breaks new ground for future research on select Flavobacteriaceae spp. as reservoirs of novel drug leads.
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