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Demonstrating morphine's potentiating effects on sucrose-intake.

S A Czirr, L D Reid

    Brain Research Bulletin
    |November 1, 1986
    PubMed
    Summary
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    Morphine sulfate decreased sucrose intake in rats during shorter sessions but increased it during longer sessions. Naloxone hydrochloride consistently reduced intake, highlighting opioid receptor roles in feeding behavior.

    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology
    • Animal Studies

    Background:

    • Opioid receptors play a complex role in regulating feeding behaviors.
    • Previous studies have yielded conflicting results regarding morphine's effect on intake.

    Purpose of the Study:

    • To investigate how morphine sulfate and naloxone hydrochloride affect sucrose intake in rats.
    • To determine the influence of test session duration on drug effects on ingestion.

    Main Methods:

    • Rats with mild water deprivation were given access to sucrose solutions for varying durations (10-100 min).
    • Rats received injections of morphine sulfate (agonist) or naloxone hydrochloride (antagonist) before or during sessions.
    • Sucrose intake was measured and analyzed based on session length and drug administration timing.

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    Main Results:

    • Naloxone hydrochloride consistently decreased sucrose intake across all session lengths.
    • Morphine sulfate decreased intake during shorter sessions (10-31 min) but increased intake during the longest session (100 min).
    • Administering morphine during a longer session (56 min into a 100-min session) also potentiated intake.

    Conclusions:

    • The duration of access to palatable solutions significantly influences the effects of opioid agonists like morphine on intake.
    • Morphine's potentiating effect on ingestion may be particularly relevant for the continuation of eating.
    • Variations in experimental designs, specifically test session length, may explain discrepancies in previous research on opioid effects on feeding.