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Variability in excess deaths across countries with different vulnerability during 2020-2023
John P A Ioannidis1,2,3,4, Francesco Zonta5, Michael Levitt6
1Department of Medicine, Stanford University, Stanford, CA 94305.
Vulnerable countries experienced significantly higher excess deaths during the COVID-19 pandemic, with poverty and lower GDP correlating with increased mortality. Country vulnerability, not just pandemic timing, determined the overall death toll.
Area of Science:
- Demography
- Epidemiology
- Public Health
Background:
- Excess deaths are key indicators of major crises like the COVID-19 pandemic.
- Accurate death registration and population data are crucial for assessing pandemic impact.
- Vulnerability indicators can help explain disparities in crisis outcomes.
Purpose of the Study:
- To evaluate excess death trajectories across countries.
- To assess the relationship between country vulnerability and excess deaths.
- To analyze excess mortality patterns by age strata.
Main Methods:
- Utilized the Human Mortality Database for 34 countries (2020-2023).
- Calculated excess deaths using 2017-2019 as reference, adjusted for 5 age strata.
- Categorized countries into 'less' and 'more' vulnerable based on GDP, income inequality (Gini), and poverty rates.
Main Results:
- Excess deaths showed inverse correlation with GDP (r=-0.60) and positive correlation with poverty (r=0.66).
- More vulnerable countries had a higher incidence rate ratio for deaths (1.062).
- Mean excess deaths were significantly higher in more vulnerable countries (7.0% and 7.2% for age groups 0-64 and >65) compared to less vulnerable ones (-0.8% and 0.4%).
Conclusions:
- Country vulnerability, defined by economic and social factors, ultimately dominated the cumulative impact of the pandemic.
- While pandemic onset varied, socioeconomic factors determined the severity of excess mortality.
- Half of the analyzed countries faced substantial excess deaths, highlighting global disparities in pandemic impact.
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