Related Experiment Video

Updated: Oct 9, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
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Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

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Risk factors for recurrent cerebral amyloid angiopathy-related intracerebral hemorrhage

Xinglei Jia1, Menghan Bo1, Hong Zhao2

  • 1VIP Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Frontiers in Neurology
|November 29, 2023
PubMed

Insights

Cerebral amyloid angiopathy-related intracerebral hemorrhage (CAA-ICH) recurs in 23% of cases. Risk factors for recurrence include prior hemorrhage, larger initial bleed volume, and specific imaging markers like superficial siderosis.

Area of Science:

  • Neurology
  • Neurosurgery
  • Radiology

Background:

  • Cerebral amyloid angiopathy (CAA) is a primary cause of lobar intracerebral hemorrhage (ICH) in older adults.
  • The recurrent nature of CAA-related ICH (CAA-ICH) contributes significantly to patient disability and mortality.
  • Understanding recurrence rates and risk factors is crucial for managing CAA-ICH.

Conclusions:

  • CAA-ICH exhibits a high recurrence rate, underscoring the need for vigilant monitoring and management.
  • Cerebral subarachnoid hemorrhage, cortical superficial siderosis (particularly disseminated), and centrum semiovale-perivascular spaces severity are key predictors of recurrent CAA-ICH.
  • Identifying these clinical and neuroimaging predictors is vital for improving patient outcomes and prognosis in CAA-ICH.
Abstract

Keywords:
cerebral amyloid angiopathycerebral small vessel diseasecortical superficial siderosisintracerebral hemorrhagerecurrence

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