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Updated: Jul 9, 2025

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Cushing Syndrome due to Adrenocortical Carcinoma During Pregnancy
Jack Andrew Morris1, Peter Campbell2, Lily Xu3
1Endocrinologist, Shoalhaven Hospital, Nowra, NSW, 2541, Australia.
Abstract:
Cushing syndrome resulting from adrenocortical carcinoma in pregnancy is exceedingly rare. There are no validated guidelines to establish a diagnosis or guide management in pregnancy. We provide a case of a 31-year-old woman presenting for management of diabetes in pregnancy who appeared cushingoid. She was subsequently diagnosed with ACTH-independent Cushing syndrome and experienced preterm labor at 33 weeks' gestation, delivering a healthy infant. Four weeks postpartum, the patient underwent a left adrenalectomy and was subsequently diagnosed with adrenocortical carcinoma.
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