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Related Experiment Video

Updated: Jul 9, 2025

Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy
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Nanobomb optical coherence elastography in multilayered phantoms.

Maryam Hatami1, Dmitry Nevozhay2, Manmohan Singh1

  • 1Department of Biomedical Engineering, University of Houston, Houston, Texas 77204, USA.

Biomedical Optics Express
|November 29, 2023
PubMed
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Researchers used laser-activated nanobombs to generate high-frequency shear waves for precise elasticity measurements in layered tissues. This technique achieved a remarkable ~65 µm resolution, advancing tissue biomechanics assessment.

Area of Science:

  • Biomedical Engineering
  • Biophysics
  • Medical Imaging

Background:

  • Layered tissue biomechanics are crucial for therapeutic monitoring.
  • Elastography using longitudinally propagating shear waves (LSWs) offers depth-dependent elasticity assessment.
  • Perfluorocarbon (PFC) nanodroplets (nanobombs) can generate localized LSWs via laser activation.

Purpose of the Study:

  • To leverage photoactivated nanobombs for high-frequency LSW generation.
  • To estimate elasticity gradients in multilayered tissues with high resolution using wave-based optical coherence elastography (OCE).
  • To demonstrate the capability of nanobomb-induced LSWs in discriminating depth-wise elasticity variations.

Main Methods:

  • Utilized multilayered tissue-mimicking phantoms.

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  • Employed laser activation of dye-loaded PFC nanodroplets to induce localized LSWs.
  • Applied wave-based optical coherence elastography (OCE) to analyze LSW propagation and speed changes.

    • Main Results:

    • Nanobomb-induced LSWs demonstrated rapid speed changes at layer interfaces.
    • Achieved an elasticity resolution of approximately 65 µm in multilayered phantoms.
    • Successfully discriminated depth-wise elasticity gradients.

    Conclusions:

    • Photoactivated nanobombs can generate LSWs suitable for high-resolution elastography.
    • This method shows significant promise for characterizing the elasticity of complex, multilayered biological tissues.
    • Potential applications in advanced therapy guidance and monitoring.