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Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
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Optimizing the Continuum of Care in Gastric Cancer

Beatrice Riccò1, Giulio Martinelli1, Camilla Bardasi1

  • 1Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.

Oncotargets and Therapy
|November 29, 2023
PubMed

Insights

Advanced gastric cancer (GC) survival remains poor despite new therapies. Research focuses on novel treatments and personalized strategies to improve outcomes for patients, especially in later treatment lines.

Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Gastric cancer (GC) is a leading cause of cancer death globally.
  • Current treatments for advanced GC, including immune checkpoint inhibitors (ICIs) and HER2-directed therapies, offer limited survival benefits, with median survival around 12 months.
  • Many patients with advanced GC are ineligible for later-line treatments due to disease aggressiveness and poor performance status.

Purpose of the Study:

  • To review the current treatment landscape for advanced gastric cancer.
  • To emphasize later-line treatment options for advanced GC.
  • To explore emerging novel therapeutic strategies and personalized approaches for advanced GC.

Main Methods:

  • Literature review of current and emerging treatments for advanced gastric cancer.
  • Analysis of treatment efficacy and patient eligibility for later-line therapies.
  • Discussion of personalized medicine strategies in advanced GC management.

Main Results:

  • Despite advancements, median survival for advanced GC remains poor.
  • A significant proportion of patients (around 60%) are not candidates for second- or later-line treatments.
  • Novel treatment options and personalized strategies are crucial for improving patient outcomes.

Conclusions:

  • There is a critical need for improved therapeutic strategies in advanced gastric cancer.
  • Optimizing the continuum of care through personalized approaches is essential.
  • Future research should focus on identifying novel treatments and enhancing patient eligibility for later-line therapies to improve survival rates.
Keywords:
continuum of caregastric cancergastroesophageal cancertarget therapies

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