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Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
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Pattern and Frequency of Nosocomial Infections in the Pediatric Intensive Care Unit at East Jeddah General Hospital,

Mohammed A Almazeedi1, Hussain A Al Ghadeer2, Amani S Bugshan1

  • 1Pediatrics, East Jeddah General Hospital, Jeddah, SAU.

Cureus
|November 29, 2023
PubMed

Insights

Pediatric intensive care unit (PICU) patients are at high risk for nosocomial infections, with central line-associated bloodstream infections (CLABSIs) being most common. Early detection and prevention strategies are crucial to reduce mortality and healthcare costs.

Area of Science:

  • Pediatric Intensive Care
  • Infectious Diseases
  • Hospital Epidemiology

Background:

  • Pediatric intensive care unit (PICU) patients face heightened vulnerability to nosocomial infections due to invasive procedures.
  • Nosocomial infections represent a significant public health concern, escalating morbidity, mortality, and healthcare expenditures.
  • Infections can develop post-PICU admission, independent of the initial critical illness.

Purpose of the Study:

  • To investigate the incidence, patterns, and clinical outcomes of nosocomial infections in pediatric ICU patients.
  • To identify the most prevalent types of nosocomial infections and causative microorganisms.
  • To determine the correlation between specific infections and mortality rates.

Main Methods:

  • Retrospective, cross-sectional study design.
  • Inclusion of pediatric patients aged one month to 14 years admitted to PICU.
  • Data collection from medical and laboratory records between 2021 and 2022.

Main Results:

  • A total of 51 patients experienced 145 nosocomial infections.
  • Central line-associated bloodstream infections (CLABSIs) were the most frequent (28.3%).
  • Gram-negative organisms predominated (58.7%), followed by fungi (35.1%) and gram-positive bacteria (6.2%).
  • The mortality rate among infected patients was 29.4%.
  • Significant correlation observed between CLABSIs, gram-negative infections, and increased mortality (p = 0.001).

Conclusions:

  • Regular surveillance systems are essential for monitoring nosocomial infections in the PICU.
  • Targeted interventions to prevent common infections like CLABSIs could enhance patient safety and be cost-effective.
  • Understanding risk factors and microbial patterns is key to mitigating adverse outcomes in critically ill children.

Keywords:
cauticlabsinosocomial infectionpediatric intensive care unit (picu)saudi arabiasepsisvap

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