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Lady Windermere Syndrome: Unravelling an Older Lady's Nightmare

Aparna Parvathaneni1, Sarat Chandra Malempati2

  • 1Internal Medicine, Gandhi Medical College, Hyderabad, IND.

Cureus
|November 29, 2023
PubMed

Insights

Nontuberculous mycobacterial (NTM) lung infection, though rare in healthy individuals, can cause bronchiectasis. This case highlights Lady Windermere Syndrome (LWS) in an immunocompetent elderly female with Mycobacterium avium complex.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Microbiology

Background:

  • Nontuberculous mycobacteria (NTM) infections are a growing cause of lung disease, especially in immunocompromised individuals.
  • Pulmonary NTM infection and bronchiectasis are uncommon in immunocompetent patients.
  • Lady Windermere Syndrome (LWS) describes this rare presentation, typically in older white females.

Observation:

  • A case of Mycobacterium avium complex (MAC) infection is presented.
  • The patient is an elderly, immunocompetent female.
  • Bronchiectasis was observed, predominantly in the middle lobe.

Findings:

  • The patient presented with clinical and radiological features consistent with Lady Windermere Syndrome.
  • Mycobacterium avium complex was identified as the causative agent.
  • The condition occurred in an immunocompetent host with no prior chronic lung disease.

Implications:

  • This case expands the understanding of NTM pulmonary disease in immunocompetent individuals.
  • Recognizing LWS is crucial for timely diagnosis and appropriate management.
  • Further research may elucidate the specific factors contributing to LWS development in susceptible populations.
Keywords:
bronchiectasislady windermere syndromemac infectiontree-in-bud nodularityvoluntary cough suppression

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