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Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
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WT1 Dendritic Cell Vaccine Therapy Improves Immune Profile and Prolongs Progression-Free Survival in End-Stage Lung

Hisashi Nagai1,2, Ryusuke Karube1

  • 1Oncology, Ginza Phoenix Clinic, Tokyo, JPN.

Cureus
|November 29, 2023
PubMed

Keywords:
cancer immunotherapychemotherapy responsedendritic cellimmune profilemetastatic non-small cell lung cancerprogression-free survivalwt1

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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