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Updated: Jul 9, 2025
00:04
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
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Pirates of Clinical Trials
Joseph Pergolizzi1, Claudio Pergolizzi2, Jo Ann K LeQuang3
1Clinical Trials, NEMA Research Inc., Naples, USA.
Cureus
|November 29, 2023
Summary
Clinical trial recruitment faces intense competition, often failing to meet goals. Larger sponsors can outbid smaller contract research organizations (CROs) for participants, creating an uneven playing field.
Area of Science:
- Clinical research operations
- Biopharmaceutical industry
- Healthcare economics
Background:
- Increasing numbers of clinical trials have intensified competition for research subjects.
- Many clinical trials struggle to achieve their participant recruitment targets.
- Contract research organizations (CROs) have expanded their roles beyond specialized functions to manage overall trial progression.
Discussion:
- CROs negotiate fixed payment agreements with sponsors per study subject.
- Sponsors with greater financial resources may increase per-subject compensation during a trial.
- This dynamic creates a competitive environment that disadvantages smaller CROs and startups.
Key Insights:
- The current market structure for clinical trial recruitment favors well-funded sponsors.
- Smaller CROs and new companies face significant challenges in securing research participants.
- Payment structures can lead to inequities in participant recruitment across different sponsor sizes.
Outlook:
- Potential strategies to mitigate disadvantages for smaller CROs and startups.
- Exploring alternative recruitment models to ensure equitable access to clinical trials.
- The impact of sponsor financial capacity on clinical trial timelines and success rates.
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