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Updated: Jun 14, 2026

Cecal Ligation Puncture Procedure

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

Gasdermins in sepsis.

Wenhua Wang¹, Zhihui He^1,2

¹Department of Intensive Care Unit, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Frontiers in Immunology

|November 29, 2023

Summary

This summary is machine-generated.

Gasdermins (GSDMs) proteins are key players in sepsis, mediating inflammatory cell death. Understanding GSDM functions offers promising therapeutic strategies to combat this complex syndrome and reduce mortality.

Keywords:

cell death gasdermin regulation sepsis therapy

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Last Updated: Jun 14, 2026

Cecal Ligation Puncture Procedure

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Published on: May 7, 2011

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

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Published on: December 9, 2022

Area of Science:

Immunology
Molecular Biology
Pathophysiology

Background:

Sepsis is a complex, hyper-heterogeneous syndrome characterized by a persistent systemic inflammatory response.
Inflammatory and immune responses dynamically change throughout sepsis pathogenesis.
Gasdermins (GSDMs) are pore-forming proteins crucial for releasing inflammatory mediators and inducing inflammatory cell death.

Purpose of the Study:

To review the diverse functions of GSDMs proteins in the context of sepsis.
To elucidate the molecular mechanisms by which GSDMs contribute to sepsis.
To explore regulatory pathways of GSDMs-mediated signaling for novel therapeutic insights.

Main Methods:

Literature review focusing on GSDMs and sepsis.
Analysis of molecular mechanisms of GSDMs in inflammatory processes.
Examination of signaling pathways regulated by GSDMs.

Main Results:

GSDMs are central executors of inflammatory cell death in sepsis.
GSDMs mediate the release of pro-inflammatory cytokines, exacerbating the systemic response.
Dysregulation of GSDMs contributes to multi-organ dysfunction in sepsis.

Conclusions:

GSDMs represent a promising therapeutic target for sepsis treatment.
A deeper understanding of GSDMs' role can lead to improved diagnostic and therapeutic strategies.
Targeting GSDMs may alleviate multi-organ dysfunction and reduce sepsis-induced mortality.