Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mechanically-gated Ion Channels

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

Urinary Bladder

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...

The Micturition Reflex

The Micturition Reflex

Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...

Non-gated Ion Channels

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Single-Cell Multiomics Pipeline Maps YBX1 as a Functional Biomarker for Immune Evasion and Therapeutic Resistance in Prostate Adenocarcinoma.

Human mutation·2026

Same author

Extreme Illuminated Vision Processing with a Graded Alloyed Perovskite In-sensor Computing Network.

Nature communications·2026

Same author

The efficacy and safety of 1470 nm diode laser in the treatment of benign prostatic hyperplasia: a prospective, multicenter study.

Lasers in medical science·2026

Same author

Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal Shock Wave Therapy through the Integrin-β1/NRF2 Axis.

The world journal of men's health·2026

Same author

Hydrostatic pressure regulates glutamine metabolism to promote bladder fibroblast activation via the Piezo1/YAP1/GLS1 axis.

Journal of translational medicine·2026

Same author

The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in <i>S. pombe</i>.

Genes & development·2025

Search research articles

Related Experiment Video

Updated: Jul 9, 2025

Ex Vivo Analysis of Mechanically Activated Ca2+ Transients in Urothelial Cells

Ex Vivo Analysis of Mechanically Activated Ca2+ Transients in Urothelial Cells

Published on: September 28, 2022

The Expression and Function of Piezo Channels in Bladder.

Zhipeng Li^1,2, Dongxu Lin^1,2, Changcheng Luo^1,2

¹Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.

Bladder (San Francisco, Calif.)

|November 29, 2023

Summary

Piezo channels are vital mechanosensors in the bladder, crucial for urinary storage and voiding. Understanding their role in bladder function and dysfunction offers new therapeutic avenues.

Keywords:

Bladder dysfunction Mechanosensitive cation channels Piezo channels

More Related Videos

Real-Time Void Spot Assay

Real-Time Void Spot Assay

Published on: February 10, 2023

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

Published on: October 6, 2022

Related Experiment Videos

Last Updated: Jul 9, 2025

Ex Vivo Analysis of Mechanically Activated Ca2+ Transients in Urothelial Cells

Ex Vivo Analysis of Mechanically Activated Ca2+ Transients in Urothelial Cells

Published on: September 28, 2022

Real-Time Void Spot Assay

Real-Time Void Spot Assay

Published on: February 10, 2023

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

Published on: October 6, 2022

Area of Science:

Physiology
Cell Biology
Urology

Background:

The bladder's ability to sense mechanical stimuli is essential for urinary storage and voiding.
Mechanosensitive ion channels, particularly Piezo1 and Piezo2, are critical for converting mechanical forces into biological signals.
These channels are implicated in various physiological and pathological processes within the bladder.

Purpose of the Study:

To systematically review the role and features of Piezo channels in bladder physiology and pathophysiology.
To highlight the significance of Piezo channels in bladder function and dysfunction.
To offer a novel perspective for future clinical treatments of bladder disorders.

Main Methods:

Systematic literature review.
Analysis of biophysical properties, cellular localization, and functional roles of Piezo channels in the bladder.
Examination of the association between Piezo channels and bladder disorders.

Main Results:

Piezo channels are key players in mechanotransduction within diverse bladder cell types.
Evidence strongly supports the functional significance of Piezo channels in normal bladder activity.
Piezo channels are linked to the development and progression of several bladder pathologies.

Conclusions:

Piezo channels are integral to bladder mechanosensation and function.
Dysregulation of Piezo channels contributes to bladder dysfunction and disease.
Further research into Piezo channels may unlock innovative therapeutic strategies for bladder conditions.