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Published on: November 1, 2017
Nanotechnology-Based Drug Delivery Systems in the Transdermal Treatment of Melanoma
Zahra Saeidi1, Rashin Giti2, Mehdi Rostami1
1Department of Pharmaceutics, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract:
The incidence rate of melanoma is dramatically increasing worldwide, raising it to the fifth most common cancer in men and the sixth in women currently. Resistance generally occurs to the agents used in chemotherapy; besides their high toxicity destroys the normal cells. This study reviewed a detailed summary of the structure, advantages, and disadvantages of nanotechnology-based drug delivery systems in the treatment of melanoma, as well as some nanocarrier applications in animal models or clinical studies. Respective databases were searched for the target keywords and 93 articles were reviewed and discussed. A close study of the liposomes, niosomes, transferosomes, ethosomes, transethosomes, cubosomes, dendrimers, cyclodextrins, solid lipid nanoparticles, and carbon nanotubes (CNTs) was conducted. It was found that these nanocarriers could inhibit metastasis and migration of melanoma cells and decrease cell viability. Conclusively, some nanocarriers like liposomes, niosomes, and transferosomes have been discussed as superior to conventional therapies for melanoma treatment.
Insights
Nanotechnology offers advanced drug delivery systems for melanoma treatment, overcoming chemotherapy resistance and toxicity. Nanocarriers like liposomes show promise over traditional therapies.
Area of Science:
- Oncology
- Nanomedicine
- Drug Delivery
Background:
- Melanoma incidence is rising globally, posing significant health challenges.
- Conventional chemotherapy for melanoma faces issues of drug resistance and high toxicity to normal cells.
Purpose of the Study:
- To review nanotechnology-based drug delivery systems for melanoma treatment.
- To summarize the structure, advantages, and disadvantages of various nanocarriers.
- To discuss nanocarrier applications in preclinical and clinical melanoma studies.
Main Methods:
- A comprehensive literature search was conducted across relevant databases.
- Ninety-three articles focusing on nanotechnology in melanoma treatment were reviewed.
- Various nanocarriers including liposomes, niosomes, and carbon nanotubes were analyzed.
Main Results:
- Nanocarriers demonstrated the ability to inhibit melanoma cell metastasis and migration.
- These systems were found to effectively decrease melanoma cell viability.
- Specific nanocarriers like liposomes, niosomes, and transferosomes exhibited superior potential.
Conclusions:
- Nanotechnology-based drug delivery systems present a promising alternative to conventional melanoma therapies.
- Certain nanocarriers offer improved efficacy and reduced toxicity for melanoma treatment.
- Further research and clinical studies are warranted to fully realize the potential of these nanomedicines.
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