Related Experiment Video
Updated: Jul 9, 2025
Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
Acute Lymphoblastic Leukemia Transformation with a Precursor B-Cell Immunophenotype to Burkitt's Lymphoma: a Case
Masoumeh Jafari1, Shahla Ansari Damavandi2, Forugh Charmduzi3
1Department of Pediatric Hematology and Oncology, Sschool of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Background:
As a new point, some very rare features can be revealed as initial diagnosis of acute lymphoblastic leukemia (ALL) without any evidence of lymphoma-like behavior which after initial recovery, presents with new evidence of lymphoma. Herein, a case of the immunophenotypes of blast cells in B-cell precursor acute lymphoblastic leukemia originated from MYC gene-related that was evidenced later by burkitt lymphoma feature.
Case Presentation:
Our case was initially diagnosed as a typical B-cell ALL cells with L1 morphology in peripheral blood smear and bone marrow aspiration that was not recovered and referred again that was finally featured as burkitt's lymphoma with L3 morphological feature.
Conclusion:
Thus, in the primary diagnosis of B-cell ALL and especially in cases with treatment failure, the final feature of burkitt's lymphoma should be potentially in mind.
More Related Videos
Related Concept Videos
01:23Cells of the Adaptive Immune Response
01:24B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
01:27Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...