Related Experiment Video
Updated: Jul 9, 2025
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
Correlation Between Cystatin C and the Severity of Cardiac Dysfunction in Patients with Systolic Heart Failure
Jiyong Ge1, Yuan Ji1, Fangfang Wang1
1Department of Cardiology, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213003, People's Republic of China.
Insights
Cystatin C levels correlate with heart failure severity, outperforming creatinine in assessing cardiac dysfunction in systolic heart failure patients.
Area of Science:
- Cardiology
- Nephrology
- Biomarkers
Background:
- Systolic heart failure (SHF) is a complex condition with significant morbidity.
- Accurate assessment of cardiac dysfunction severity is crucial for effective management.
- Novel biomarkers are needed to improve diagnostic and prognostic capabilities.
Purpose of the Study:
- To investigate the relationship between cystatin C and the severity of cardiac dysfunction in patients with systolic heart failure.
- To compare the utility of cystatin C with creatinine in evaluating heart failure severity.
Main Methods:
- 100 hospitalized patients with SHF and 100 age-gender-matched controls were recruited.
- Serum concentrations of cystatin C, creatinine, and B-type natriuretic peptide (BNP) were measured.
- Transthoracic echocardiography was performed to assess cardiac structure and function.
Main Results:
- Cystatin C and other renal function indices were elevated in SHF patients, particularly those with severe dysfunction.
- Cystatin C showed significant positive associations with BNP and left atrial diameter, and a negative association with ejection fraction.
- Cystatin C demonstrated superior diagnostic performance (AUC = 0.893) compared to creatinine (AUC = 0.764) in identifying severe cardiac dysfunction (NYHA III/IV).
Conclusions:
- Cystatin C is significantly correlated with cardiac structure and function in systolic heart failure.
- Cystatin C is a more valuable biomarker than creatinine for evaluating the severity of heart failure.
Introduction:
To investigate the relationship between cystatin C and cardiac dysfunction severity in patients with systolic heart failure.
Methods:
We recruited 100 hospitalized patients with systolic heart failure and 100 age-gender-matched controls. The clinical information of each patient was collected. Blood pressure, heart rate, height, and weight were measured, as were serum concentrations of cholesterol, renal function indices, cystatin C, and B-type natriuretic peptide (BNP). Transthoracic echocardiography was performed on each patient.
Results:
Cystatin C and other indices of renal function, such as urea nitrogen, creatinine, and uric acid, were significantly elevated in the serum of patients with heart failure and those with more severe cardiac dysfunction. The stepwise regression analyses showed that cystatin C was positively associated with BNP (β = 0.18, P = 0.04, 95% CI: 21.1 ~ 1420.4) and left atrial diameter (LAD) (β = 0.19, P = 0.04, 95% CI: 0.03 ~ 9.21) and was negatively associated with ejection fraction (β = -0.22, P = 0.023, 95% CI: -12.4 ~ -0.93), while creatinine was only positively correlated with BNP (β = 0.23, P = 0.03, 95% CI: 1.11 ~ 20.7). The Receiver Operating Characteristic (ROC) curves demonstrated significantly more severe cardiac dysfunction (NYHA III/IV) in patients with cystatin C ≥ 0.895mg/L (sensitivity was 83.0%, specificity was 80.9%, AUC = 0.893) and creatinine ≥ 91.5μmol/L (sensitivity was 71.7%, specificity was 70.2%, AUC = 0.764).
Conclusion:
Cystatin C was significantly correlated with cardiac structure and function in patients with systolic heart failure, and it was more valuable than creatinine to evaluate the severity of heart failure.
More Related Videos
10:12A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
Published on: August 8, 2013
12:45Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:17Pathophysiology of Heart Failure
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:22Heart Failure Drugs: Diuretics
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
01:26Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...