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Genetic Polymorphisms Involved in Bladder Cancer: A Global Review
Hampig Raphael Kourie1, Joseph Zouein1, Bahaa Succar1
1Hematology-Oncology Department, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Oncology Reviews
|November 29, 2023
Summary
Genetic variations, specifically single nucleotide polymorphisms (SNPs), influence bladder cancer (BC) risk. This study identified key genes and SNPs consistently linked to BC susceptibility, excluding environmental factors.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Bladder cancer (BC) exhibits genetic susceptibility.
- Single nucleotide polymorphisms (SNPs) are known to influence BC risk.
- Previous research has identified numerous genetic associations with BC.
Purpose of the Study:
- To systematically review and identify genes and SNPs associated with bladder cancer.
- To focus on genetic factors independent of smoking and environmental exposures.
- To classify the identified genetic variants by function.
Main Methods:
- A comprehensive literature search was conducted from January 2000 to October 2020.
- 334 articles reporting 455 SNPs in 244 genes were initially selected.
- SNPs linked to smoking and environmental factors were excluded, followed by analysis of congruent results.
Main Results:
- A total of 197 genes and 343 SNPs were found to be associated with BC.
- 177 genes and 291 SNPs demonstrated congruent results across studies.
- These validated genes and SNPs were functionally categorized into eight groups.
Conclusions:
- Specific genes and SNPs are consistently associated with bladder cancer genetic susceptibility.
- This curated list of genetic factors provides a foundation for further BC research.
- Understanding these genetic underpinnings can aid in identifying at-risk individuals.
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