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Related Experiment Videos

Clindamycin phosphate kinetics in subjects undergoing CAPD.

M T Schwartz, S F Kowalsky, E M McCormick

    Clinical Nephrology
    |December 1, 1986
    PubMed
    Summary

    Intraperitoneal clindamycin phosphate effectively treats peritonitis in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). This administration route also shows promise for systemic infections when intravenous access is unavailable.

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    Area of Science:

    • Pharmacokinetics
    • Nephrology
    • Infectious Diseases

    Background:

    • Continuous ambulatory peritoneal dialysis (CAPD) patients are susceptible to peritonitis.
    • Intraperitoneal antibiotic administration is a common treatment strategy for CAPD-related peritonitis.

    Purpose of the Study:

    • To investigate the pharmacokinetics of intraperitoneally administered clindamycin phosphate in CAPD patients.
    • To evaluate the efficacy of intraperitoneal clindamycin phosphate for treating CAPD-related peritonitis and potential systemic infections.

    Main Methods:

    • Nine volunteers undergoing CAPD were divided into two groups.
    • Group I received 300 mg/L clindamycin phosphate in exchanges 1-5; Group II received 300 mg/L in exchange 1 and 30 mg/L in exchanges 2-5.
    • Serum and dialysate clindamycin levels were measured using bioassay.

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    Main Results:

    • Clindamycin phosphate was rapidly activated upon intraperitoneal administration.
    • Peak serum concentrations of clindamycin were achieved quickly in both groups.
    • Group I subjects reached peak serum levels within 3 hours (3.94 ug/ml), and Group II within 5 hours (7.35 ug/ml).

    Conclusions:

    • Intraperitoneal clindamycin phosphate is effective for treating CAPD-related peritonitis.
    • This route is a viable option for treating systemic infections in patients lacking intravenous access.