Related Experiment Video

Updated: Aug 20, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat

Published on: June 4, 2012

15.8K

Vancomycin associated acute kidney injury in patients with infectious endocarditis: a large retrospective cohort

Pan Kunming1, Huang Ying2,3,4, Xu Chenqi2,3

  • 1Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, China.

Frontiers in Pharmacology
|November 29, 2023
PubMed

Insights

Vancomycin-associated acute kidney injury (VA-AKI) occurred in 17% of infective endocarditis patients. Risk factors include contrast agents and longer vancomycin therapy, necessitating closer monitoring.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Background:

  • Vancomycin is a primary treatment for infective endocarditis (IE).
  • Vancomycin is linked to nephrotoxicity, but its impact on acute kidney injury (AKI) in IE patients is not well-defined.
  • This study investigates vancomycin-associated AKI (VA-AKI) in IE patients.

Purpose of the Study:

  • To determine the incidence, risk factors, and prognosis of VA-AKI in patients with IE.
  • To identify specific patient characteristics and treatment parameters associated with VA-AKI development.

Main Methods:

  • A large retrospective cohort study.
  • Included adult patients diagnosed with IE receiving vancomycin.
  • Primary outcome was the development of VA-AKI.

Main Results:

  • The incidence of VA-AKI was 17.01% among 435 enrolled IE patients.
  • Independent risk factors for VA-AKI included higher BMI, longer vancomycin duration, pre-existing CKD, ICU admission, and concomitant radiocontrast agents.
  • Vancomycin variety (Lai Kexin vs. Wen Kexin) was a protective factor; therapy >10.75 days increased VA-AKI risk.

Conclusions:

  • VA-AKI incidence in IE patients is notable, slightly higher than in the general population.
  • Concomitant contrast agents significantly elevate nephrotoxicity risk (2-fold) in IE patients.
  • Extended vancomycin therapy (>10.75 days) and contrast use warrant closer renal function and vancomycin level monitoring.
Keywords:
acute kidney injuryduration of therapyinfectious endocarditisrisk factorsvancomycin

More Related Videos

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury07:03

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury

Published on: February 15, 2022

1.5K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.5K

Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...