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Related Experiment Videos

Atenolol for ventricular ectopy: a dose-response study.

P E Fenster, D Reynolds, L D Horwitz

    Clinical Pharmacology and Therapeutics
    |January 1, 1987
    PubMed
    Summary
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    Atenolol showed limited efficacy in reducing overall ventricular ectopic depolarizations but was more effective in suppressing ventricular tachycardia. Adverse effects led to discontinuation in some patients.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Ventricular ectopic depolarizations (VEDs) are common arrhythmias.
    • Assessing antiarrhythmic drug efficacy is crucial for patient management.

    Purpose of the Study:

    • To evaluate the antiarrhythmic efficacy, safety, and tolerance of atenolol in patients with VEDs.
    • To determine the optimal dosage of atenolol for VED suppression.

    Main Methods:

    • A single-blind, placebo-controlled study involving 32 patients with at least 60 VEDs/hr.
    • Patients received placebo or atenolol (50, 100, 200 mg daily) for 2-week periods.
    • 24-hour ambulatory ECG monitoring was performed weekly.

    Main Results:

    • Atenolol did not significantly reduce overall VED frequency across tested doses.

    Related Experiment Videos

  • Significant reduction in ventricular tachycardia frequency was observed with atenolol.
  • 12 patients discontinued atenolol due to adverse effects.

    • Conclusions:

    • Atenolol demonstrates greater efficacy in suppressing ventricular tachycardia compared to overall ventricular ectopy.
    • Atenolol's effectiveness in VED suppression is dose-dependent but not statistically significant.
    • Safety and tolerance of atenolol require careful consideration due to adverse events.