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Complex relationship between gut microbiota and thyroid dysfunction: a bidirectional two-sample Mendelian

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  • 1Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

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|November 29, 2023
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Summary
This summary is machine-generated.

Certain gut bacteria increase thyroid dysfunction risk, while others offer protection. This study clarifies the gut-thyroid connection, aiding targeted probiotic use for thyroid health.

Keywords:
Mendelian randomizationgut microbiotahypothyroidismthyroid dysfunctionthyroid-gut axis

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Area of Science:

  • Microbiome research
  • Endocrinology
  • Human genetics

Background:

  • The relationship between gut microbiota and thyroid dysfunction is established, but causal links and post-onset changes remain unclear.
  • Understanding this bidirectional interaction is crucial for thyroid health management.

Purpose of the Study:

  • To investigate the causal effect of gut microbiota on thyroid dysfunction using a two-sample Mendelian randomization (MR) approach.
  • To explore alterations in gut microbiota composition following the onset of hypothyroidism.

Main Methods:

  • A two-sample MR study utilizing data from the MiBioGen consortium for 211 bacterial taxa and thyroid dysfunction data from multiple databases.
  • Employing various statistical methods including Inverse Variance Weighting (IVW) and sensitivity analyses.
  • Conducting a reverse MR study to examine gut microbiota changes after hypothyroidism onset.

Main Results:

  • Specific bacterial genera (e.g., *Intestinimonas*, *Eubacterium brachy group*) were identified as risk factors for reduced thyroid function.
  • Other genera (*Bifidobacterium*, *Lachnospiraceae UCG008*) and phyla (Actinobacteria, Verrucomicrobia) demonstrated protective effects.
  • The abundance of eight bacterial taxa was found to change after hypothyroidism onset, with no significant heterogeneity or pleiotropy detected.

Conclusions:

  • This study systematically elucidates the complex interplay between gut microbiota and thyroid dysfunction.
  • Findings support the development of targeted probiotic strategies to maintain thyroid-gut axis homeostasis and manage thyroid disorders.