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Updated: Jul 9, 2025

Development of New Therapeutic Applications Using Microfluidics
Published on: October 1, 2007
Exploring team dynamics during the development of a multi-institutional cross-disciplinary translational team:
Joseph A Kotarba1,2, Stephen Molldrem1,3, Elise Smith1,3
1Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USA.
Introduction:
A recent literature review revealed no studies that explored teams that used an explicit theoretical framework for multiteam systems in academic settings, such as the increasingly important multi-institutional cross-disciplinary translational team (MCTT) form. We conducted an exploratory 30-interview grounded theory study over two rounds to analyze participants' experiences from three universities who assembled an MCTT in order to pursue a complex grant proposal related to research on post-acute sequelae of COVID-19, also called "long COVID." This article considers activities beginning with preliminary discussions among principal investigators through grant writing and submission, and completion of reviews by the National Center for Advancing Translational Sciences, which resulted in the proposal not being scored.
Methods:
There were two stages to this interview study with MCTT members: pre-submission, and post-decision. Round one focused on the process of developing structures to collaborate on proposal writing and assembly, whereas round two focused on evaluation of the complete process. A total of 15 participants agreed to be interviewed in each round.
Findings:
The first round of interviews was conducted prior to submission and explored issues during proposal writing, including (1) importance of the topic; (2) meaning and perception of "team" within the MCTT context; and (3) leadership at different levels of the team. The second round explored best practices-related issues including (1) leadership and design; (2) specific proposal assembly tasks; (3) communication; and (4) critical events.
Conclusion:
We conclude with suggestions for developing best practices for assembling MCTTs involving multi-institutional teams.
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