DNA oxidation after exercise: a systematic review and meta-analysis.
Mengxin Ye1,2, Luthfia Dewi2, Yu-Chieh Liao2
1College of Physical Education and Science, Zhejiang Normal University, Jinhua, China.
Frontiers in Physiology
|November 29, 2023
Summary
Resistance exercise increases 8-hydroxy-2′-deoxyguanosine (8-OHdG) in trained and untrained adults. Aerobic exercise shows varied effects, with high-intensity sessions increasing 8-OHdG in trained individuals, suggesting a role in adaptation.
Area of Science:
- Exercise physiology
- Biomarkers of oxidative stress
- DNA damage and repair
Background:
- 8-Hydroxy-2′-deoxyguanosine (8-OHdG) is a marker of DNA oxidation.
- Despite being a damage byproduct, 8-OHdG may paradoxically promote tissue healing.
- The impact of exercise on 8-OHdG levels requires further elucidation.
Approach:
- Systematic review and meta-analysis of 16 studies.
- Included resistance and aerobic exercise interventions.
- Analyzed 431 participants, comparing trained and untrained individuals.
Key Points:
- Resistance exercise significantly increased circulating 8-OHdG in both trained and untrained adults.
- Aerobic exercise yielded mixed results: small increase in trained, large decrease in untrained individuals (long-duration).
- High-intensity aerobic exercise increased 8-OHdG primarily in trained individuals.
Conclusions:
- Resistance exercise consistently elevates 8-OHdG levels.
- The response to aerobic exercise is complex and depends on intensity and duration.
- Elevated 8-OHdG post-high-intensity aerobic exercise in trained individuals may indicate a role in training adaptation.
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