Related Experiment Video

Updated: Jul 9, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.1K

Complex interplay of gut microbiota between obesity and asthma in children

Mingge Hu1, Xiaoman Zhao1, Yazun Liu1

  • 1Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Frontiers in Microbiology
|November 29, 2023
PubMed

Insights

Childhood obesity and asthma are linked, with gut bacteria playing a key role in obesity-related asthma. Understanding this gut microbiota connection may lead to new treatments.

Area of Science:

  • Pediatric Allergy and Immunology
  • Microbiome Research
  • Metabolic Health

Background:

  • Obesity is a significant risk factor and comorbidity for childhood asthma.
  • Obesity-related asthma is a distinct phenotype associated with severe symptoms and reduced quality of life.
  • Early-life gut microbiota establishment is crucial for immune and metabolic development in children.

Purpose of the Study:

  • To review the interplay between asthma and obesity in children.
  • To focus on the mediating role of gut microbiota in obesity-related asthma pathogenesis.
  • To provide insights for understanding and potentially treating this condition.

Main Methods:

  • Literature review of recent research on asthma, obesity, and gut microbiota.
  • Analysis of the mechanisms linking microbial dysbiosis to metabolic and immune alterations.
  • Synthesis of evidence on the transitional role of gut microbiota in obesity-related asthma.

Main Results:

  • Microbial dysbiosis affects lipid metabolism, inflammation, and immune responses.
  • Gut microbiota dysbiosis is linked to susceptibility to childhood obesity and asthma.
  • The gut microbiota plays a crucial role in the progression of obesity-related asthma.

Conclusions:

  • The gut microbiota is a key factor in the pathogenesis of obesity-related asthma.
  • Targeting the gut microbiota may offer novel therapeutic strategies for childhood obesity-related asthma.
  • Further research is needed to fully elucidate these complex interactions and develop interventions.

Keywords:
asthmachildrenchronic low-grade inflammationgut microbiotaimmunelipid metabolismobesity

More Related Videos

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.2K
Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells06:07

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

6.7K

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.1K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
411
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
507
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.5K