Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

2.0K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.0K
Bone Remodeling01:40

Bone Remodeling

38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Aging01:26

Aging

56
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
56
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dimension-controlled formation of crease patterns on soft solids.

Soft matter·2016
Same author

Modeling Day-to-day Flow Dynamics on Degradable Transport Network.

PloS one·2016
Same author

Tetramethylpyrazine Protects Against Glucocorticoid-Induced Apoptosis by Promoting Autophagy in Mesenchymal Stem Cells and Improves Bone Mass in Glucocorticoid-Induced Osteoporosis Rats.

Stem cells and development·2016
Same author

Corrigendum: Lithium-ion-based solid electrolyte tuning of the carrier density in graphene.

Scientific reports·2016
Same author

PTEN/PI3K/AKT protein expression is related to clinicopathological features and prognosis in breast cancer with axillary lymph node metastases.

Human pathology·2016
Same author

Comparing the Diagnostic Accuracy of RTE and SWE in Differentiating Malignant Thyroid Nodules from Benign Ones: a Meta-Analysis.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology·2016
Same journal

Lifelong Consumption of Freeze-Dried Parabacteroides Distasonis Improves Gut Barrier Integrity and Extends Lifespan and Health Span in Drosophila Melanogaster.

Aging and disease·2026
Same journal

Chronogeroprotection: Circadian Action Bundles for Healthy Aging.

Aging and disease·2026
Same journal

Targeting Cellular Senescence as a Therapeutic Strategy to Attenuate Pulmonary Fibrosis Associated with Metabolic Syndrome.

Aging and disease·2026
Same journal

Muscle-Brain Crosstalk in Alzheimer's Disease: Exercise-Associated FNDC5/Irisin Pathways in Preclinical Models - A Systematic Review.

Aging and disease·2026
Same journal

Extracellular Space Barrier Dysfunction Disrupts Interstitial Fluid Drainage and Is Associated with Memory Heterogeneity in Cognitive Aging.

Aging and disease·2026
Same journal

Rapamycin Attenuates Age-Related Changes in Marmoset Submandibular Gland: A Non-Human Primate Model of Human Oral Aging.

Aging and disease·2026
See all related articles

Related Experiment Video

Updated: Jul 9, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.4K

Consequences of Aging on Bone.

Lingli Zhang1, Qiao Guan2, Zhikun Wang2

  • 1College of Athletic Performance, Shanghai University of Sport, Shanghai, China.

Aging and Disease
|November 29, 2023
PubMed
Summary
This summary is machine-generated.

Aging significantly alters the bone microenvironment, promoting fat accumulation and favoring bone resorption over formation. This review explores age-related changes in skeletal cells and their impact on musculoskeletal health.

More Related Videos

Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

2.2K
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

329

Related Experiment Videos

Last Updated: Jul 9, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.4K
Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

2.2K
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

329

Area of Science:

  • Gerontology
  • Skeletal Biology
  • Musculoskeletal Health

Background:

  • Global population aging increases musculoskeletal disease incidence.
  • Skeletal microenvironment shifts towards bone resorption and fat accumulation with age.
  • Cellular senescence and altered skeletal stem/stromal cell (SSCs) fate (adipogenesis over osteogenesis) are key aging features.

Purpose of the Study:

  • Systematically review aging effects on bone and its microenvironment.
  • Investigate age-related changes in skeletal cells, vascularization, innervation, and marrow fat.
  • Elucidate osteoimmune regulation mechanisms in aging bone and their link to musculoskeletal diseases.

Main Methods:

  • Systematic literature review.
  • Analysis of age-related changes in skeletal cells (SSCs, osteoblasts, osteocytes, macrophage-lineage cells).
  • Examination of microenvironmental factors: vascularization, innervation, marrow fat, and lymphatic system.

Main Results:

  • Aging promotes SSC adipogenesis, osteoblast/osteocyte apoptosis, and functional decline.
  • Enhanced osteoclast activity and impaired vascular/nerve function characterize aging bone.
  • Age-related shifts in osteoimmune balance contribute to musculoskeletal disease pathogenesis.

Conclusions:

  • Aging profoundly disrupts bone homeostasis through cellular and microenvironmental changes.
  • Understanding these age-related osteoimmune mechanisms is crucial for developing therapeutic strategies.
  • Targeting age-induced bone alterations may mitigate musculoskeletal disease progression.