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Molecular glues targeting GSPT1 in cancers: A potent therapy

Dandan Zhang1, Pei Lin1, Jun Lin1

  • 1School of Life sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.

Bioorganic Chemistry
|November 29, 2023
PubMed

Insights

Molecular glues targeting GSPT1 offer a novel therapeutic strategy for cancer. By hijacking the ubiquitination-proteasomal system, these compounds degrade overexpressed GSPT1, showing promise in cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • G1 to S phase transition 1 (GSPT1) is overexpressed in various cancers.
  • Molecular glues are small molecules that recruit neosubstrate proteins for degradation via E3 ligases like cereblon (CRBN).
  • This approach holds potential for treating cancers and other diseases.

Conclusions:

  • Molecular glues targeting GSPT1 represent a promising anticancer strategy.
  • Further research into their pharmacology and development is warranted.
  • This review provides insights for future studies in this field.
Keywords:
CRBNGSPT1Molecular gluePROTACeRF3

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