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Optically active two-dimensional MoS2-based nanohybrids for various biosensing applications: A comprehensive review.

Sandip Ghosh1, Chia-Jung Yang1, Jui-Yang Lai2

  • 1Department of Biomedical Engineering, Chang Gung University, Taoyuan, 33302, Taiwan.

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|November 29, 2023
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Summary

Molybdenum disulfide (MoS2) nanocrystals are emerging as versatile materials for advanced bio/immunosensors. Their unique tunable properties offer significant potential for enhanced biosensing applications.

Keywords:
2D materialsBiosensorsElectrochemistryLimit of detectionMoS(2) nanohybrid

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Two-dimensional (2D) nanomaterials, like graphene, have spurred interest in alternatives such as molybdenum disulfide (MoS2).
  • MoS2 exhibits layer-dependent band gaps and strong light interaction, making it suitable for biosensing.
  • Its tunable size, shape, and properties (optical absorption, electron mobility, mechanical strength, surface area) are advantageous for sensor development.

Purpose of the Study:

  • To review the advancements in bio/immunosensing applications utilizing MoS2 and its nanohybrids.
  • To explore synthesis, characterization, and functionalization methods for 2D MoS2 nanosheets.
  • To discuss fabrication techniques, performance metrics, and clinical implications of MoS2-based biosensors.

Main Methods:

  • Review of literature on MoS2 synthesis and characterization.
  • Analysis of functionalization strategies for MoS2 nanosheets.
  • Discussion of various biosensor fabrication techniques and performance evaluation.

Main Results:

  • MoS2 nanocrystals demonstrate significant potential as probe materials for optical, photothermal, and electrical bio/immunosensors.
  • Tunable properties of MoS2 enhance biosensor performance, including sensitivity and limit of detection.
  • Various synthesis and functionalization routes for 2D MoS2 have been developed.

Conclusions:

  • MoS2-based biosensors offer promising advancements over existing technologies.
  • Further research is needed to address limitations and explore clinical implications.
  • This review provides a comprehensive overview to guide future development in MoS2 biosensing.